Moral/metaphysical imbalance can be destructive in the same way that physical imbalance can be destructive. The ‘sins’ can be seen as moral poisons. This should not be seen as any sort of absolute such as ‘sickness’ means you have been bad or ‘if you get ill it’s your own fault for being wicked or negative’. Good people get ill and some ‘wicked’ people live long and prosper. Maybe everyone has a particular moral ecology or moral sensitivity just as they have different physical sensitivities such as more or less tolerance for alcohol.